“ ’ ’ [ 53 . ! a ’ ” ’ ’ ’ ’ ”
نویسنده
چکیده
The accelerating trend toward Faster, Better, Cheaper (FEE) missions places increasing emphas is on the trade-offs between requirements and risk to reduce cost and development times, while still improving quality and reliability. The Risk/Requirenlents Trade-off Guidelines discussed in this paper are part of an integrated approach to address the main issues by focusing on the sum of prevention, analysis, control or test (PACT) processes. This approach maps weighted risk (or failure modes) against detection or prevention options to provide a mechanism for performing risk/resource tradeoffs. The population of this matrix can be done a “row at a time” by examining the value added of each requirement or PACT, in terms of risk reduction, This row by row development is the principle focus of the guidelines described herein. Cost drivers in the performance of these specific areas are identified for potential trade-off studies. Parametric trade-offs that would be cost effective are indicated and effective substitutes for specific requirements are discussed.
منابع مشابه
The recycling pathway of protein ERGIC-53 and dynamics of the ER-Golgi intermediate compartment.
To establish recycling routes in the early secretory pathway we have studied the recycling of the ER-Golgi intermediate compartment (ERGIC) marker ERGIC-53 in HepG2 cells. Immunofluorescence microscopy showed progressive concentration of ERGIC-53 in the Golgi area at 15 degreesC. Upon rewarming to 37 degreesC ERGIC-53 redistributed into the cell periphery often via tubular processes that largel...
متن کاملCargo selectivity of the ERGIC-53/MCFD2 transport receptor complex.
Exit of soluble secretory proteins from the endoplasmic reticulum (ER) can occur by receptor-mediated export as exemplified by blood coagulation factors V and VIII. Their efficient secretion requires the membrane lectin ER Golgi intermediate compartment protein-53 (ERGIC-53) and its soluble luminal interaction partner multiple coagulation factor deficiency protein 2 (MCFD2), which form a cargo ...
متن کاملThe spectrum of visceral injuries secondary to misplaced intercostal chest drains: experience from a high volume trauma service in South Africa.
INTRODUCTION Iatrogenic visceral injuries (IVI) secondary to the insertion of an intercostal chest drain (ICD) are well documented, but are usually confined to case reports and small series. MATERIALS AND METHODS We reviewed our experience with 53 consecutive patients over a insertion seven year period who sustained an IVI secondary to an ICD and describe the spectrum of injuries and clinical...
متن کاملNon-Ambulant Duchenne Patients Theoretically Treatable by Exon 53 Skipping have Severe Phenotype
BACKGROUND Exon skipping therapy is an emerging approach in Duchenne Muscular Dystrophy (DMD). Antisense oligonucleotides that induce skipping of exon 51, 44, 45, or 53 are currently being evaluated in clinical trials. These trials were designed on the basis of data available in general DMD population. OBJECTIVES Our objective was to compare the clinical and functional statuses of non-ambulan...
متن کاملAttenuation markers of a candidate dengue type 2 vaccine virus, strain 16681 (PDK-53), are defined by mutations in the 5' noncoding region and nonstructural proteins 1 and 3.
The genome of a candidate dengue type 2 (DEN-2) vaccine virus, strain PDK-53, differs from its DEN-2 16681 parent by nine nucleotides. Using infectious cDNA clones, we constructed 18 recombinant 16681/PDK-53 viruses to analyze four 16681-to-PDK-53 mutations, including 5' noncoding region (5'NC)-57 C-to-T, premembrane (prM)-29 Asp-to-Val (the only mutation that occurs in the structural proteins)...
متن کاملunc-53 controls longitudinal migration in C. elegans.
Cell migration and outgrowth are thought to be based on analogous mechanisms that require repeated cycles of process extension, reading and integration of multiple directional signals, followed by stabilisation in a preferred direction, and renewed extension. We have characterised a C. elegans gene, unc-53, that appears to act cell autonomously in the migration and outgrowth of muscles, axons a...
متن کامل